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說明
UNcle:一站式 多參數生物製劑、蛋白質穩定性分析儀。

    UNcle集成全光譜螢光、SLS與DLS三種測量科技於一身,搭配溫控與獨特的UNi Cuvette(48個樣品,9μL體積,防蒸發設計),可在相同的樣品與時間進行多種蛋白質穩定參數量測.UNi 是微量石英Cuvette,僅需要9μL的樣品.裝載 到金屬卡槽,並用矽膠密封,可以確保高效溫度傳導與高密封性.非常適合進行長時間與高溫的穩定性試驗.

 

蛋白質穩定性參數:Tm, Tagg Thermo-Recovery測量超簡單

    UNcle 可同時測量全光譜螢光與SLS,搭配溫度控制 可以快速得到Tm1, Tm2與Tagg,可快速選擇Clone 與 Formulation .不管使用蛋白質內生性螢光或是 SYPRO都可以進行偵測;使用UNcle, Thermo-Recovery 實驗超簡單. 同時使用螢光偵測 folding / unfolding , 與SLS量 測粒徑變化.實驗前後使用DLS測量大小與質量 分佈,輕鬆了解蛋白耐熱程度與Formulation的好壞.



AAV基因治療載體穩定測試:

    UNcle具有測試AAV, adeno associated virus, 病毒載體穩定性測試呢能力;除了外殼穩定性(Capsid stability)外,也可以測試基因外洩(genome ejection)與病毒聚集的狀況,觀察不同溫度下病毒載體的變化,快速挑選適合的病毒載體.



法規? 沒問題

    UNcle 提供IOQ文件與支援21 CFR Part11規範的軟體。Unchained labs的產品已被廣大生物製劑廠採用。



測量參數:

  • Tm & Tagg

  • Tm with SYPRO (DSF)

  • Isothermal stability

  • Sizing & polydispersity

  • Sizing with thermal ramp

  • Thermal recovery

  • Viscosity

  • kDB22

  • G22

  • ΔG

  • Viral capsid stability



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Description
One-stop stability

Cracking stability using a pile of one-trick, protein-hungry tools is a ton of work. Uncle combines 3 different measurement modes — fluorescence, Static Light Scattering (SLS) and Dynamic Light Scattering (DLS). So you can crank out all your data in just a few hours, and use way less protein. All the info you’ll get makes picking the best formulation, protein, or viral vector a piece of cake.

 

Uncover way more in one shot

Trying new formulations or constructs? Get answers for up to 48 samples in under 2 hours. Measure Tm and Tagg at the same time and know when unfolding leads to aggregation. Add a DLS read before the temp ramp to know if you’ve got aggregate trouble right out of the gate.

 

AAV capsid stability

Uncle teams up with SYBR Gold to get a read on when your DNA starts to leak — way before the AAV capsid pops. Quantify initial free DNA and the amount that’s on the loose after a thermal ramp. Know when aggregation gets out of hand and tackle particle titer with SLS and DLS.

 

B22 & kD

Get B22 and kD at the same time in the same Uni. Or, switch over to G22 if you’re working at super high concentrations. Learn on the spot if your protein-formulation combo is good to go or risky for aggregation with software that makes things easy to figure out. For super high protein concentrations, G22 is ready to go.

 

Unleash the Uni

Get more data with way less protein. The Uni only needs 9 μL of sample, and you pick how you use it. Run 1 sample in the morning, 48 in the afternoon. Do a DLS read if that’s all you need. Or, check DLS, then start a 3-day experiment to monitor real-time stability. Your samples are sealed airtight, so runs can be short or long — your call.

 

Full-spectrum

Biologics behave differently. With Uncle, you get the whole fluorescence spectrum, so you don’t need to know ahead of time how your protein behaves. If you want to try out some new tricks with dyes, Uncle can pick up on those too. Uncle catches aggregation with two wavelengths — so you’ll see it no matter what.

 

21CFRp11

If you’re working in regulated environments, you know that controlling access to data and keeping its integrity are a must-have. Uncle has 21CFRp11 compliant software tools that can be turned on without a hitch.

 

 
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