Comprehensive Preclinical MRI Contrast Agents - Viscover Portfolio Overview
Viscover presents the industry's first comprehensive portfolio of dedicated animal imaging agents, featuring GadoSpin™ gadolinium chelates and FeraSpin™ iron oxide nanoparticles. These innovative MRI contrast agents unleash the full potential of preclinical animal MRI research, employing cutting-edge technologies from small molecules to advanced nanoparticles.
GadoSpin™ Gadolinium-Based Contrast Agent Series
GadoSpin M serves as the trusted extracellular MRI agent, rapidly distributing in vascular and interstitial spaces without permeating cell membranes or the intact blood-brain barrier. This clinically proven formulation excels in investigating blood-brain barrier abnormalities in brain tumors and neuroinflammation, while providing enhanced soft-tissue contrast for whole-body imaging applications.
GadoSpin P, a long-circulating blood pool agent, revolutionizes magnetic resonance angiography (MRA) with its high molecular weight polymer structure. Unlike conventional Gd-DTPA that rapidly extravasates, GadoSpin P maintains prolonged intravascular retention, enabling higher resolution vascular imaging with extended acquisition timeframes and superior vessel delineation.
GadoSpin D represents a unique dendritic MRI agent containing 24 gadolinium ions in a globular structure, specifically designed for dynamic contrast-enhanced (DCE) MRI studies. This innovative agent enables precise quantification of blood vessel integrity, tumor angiogenesis, and anti-angiogenic therapy monitoring through temporal sampling and exchange rate constant calculations.
GadoSpin F features a hydrophobic targeting moiety with high protein binding affinity, specifically developed for atherosclerosis imaging. This specialized agent accumulates in atherosclerotic plaques, enabling direct T1-weighted visualization and quantitative assessment of plaque burden in preclinical cardiovascular disease models.
FeraSpin™ Superparamagnetic Iron Oxide Nanoparticle Series
FeraSpin R, based on clinically proven Ferucarbotran technology, forms the foundation of the FeraSpin product family. These superparamagnetic iron oxide (SPIO) nanoparticles (10-90 nm) are rapidly taken up by liver and spleen macrophages, delivering optimal T2/T2* contrast. FeraSpin R excels in liver and spleen visualization, liver tumor morphology assessment, and nanoparticle physiology studies.
FeraSpin XS represents the ultrasmall particle fraction (10-20 nm) with extended blood circulation properties, ideal for whole-body T1-weighted MR angiography, vascular fine structure visualization, and stem cell tracking applications.
The FeraSpin Series (XS to XXL) comprises six size-selected SPIO fractions with identical chemical composition and ultra-narrow size distribution, creating a unique research toolbox for nanoparticle MRI investigations. Particle sizes range from 10 nm (XS) to 70 nm (XXL), with r2/r1 relaxivity ratios spanning 3-46, enabling fine-tuning of pharmacologic profiles for extended circulation or organ-specific uptake applications.
Comprehensive Application Spectrum
Viscover MRI Portfolio supports diverse preclinical research applications including tumor vascularization and angiogenesis studies, cardiovascular disease imaging, tissue delineation and organ-specific imaging, magnetic resonance angiography, therapeutic efficacy monitoring, nanoparticle physiology investigations, stem cell tracking, MR sequence development, and Magnetic Particle Imaging (MPI) research.
These innovative contrast agents employ advanced nanotechnologies, surpassing human clinical routine standards while maintaining compatibility with established clinical agents. Viscover's commitment to excellence extends to custom solutions including agent development, pharmaceutical manufacturing, and experiment design consultation, supporting collaborative opportunities from pilot studies to long-term research partnerships.
All Viscover products are manufactured for research use only, designed specifically for small animal preclinical MRI studies. The comprehensive portfolio enables researchers to select optimal imaging agents based on specific experimental requirements, particle size preferences, relaxation properties, circulation time, and organ-specific targeting needs.
Discover how GadoSpin and FeraSpin products can advance your preclinical MRI research with unprecedented imaging capabilities, from molecular-level visualization to whole-body angiography, from tumor microenvironment characterization to nanoparticle biodistribution studies.
