公開演講

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Effortless ADC Characterization ： Three Tools, One Seamless Workflow

ADC 分析不費力，三機聯手一氣呵成！

Aunty 穩定性分析、Stunner 濃度＋粒徑、Unagi 智換Buffer

May 12^th (Monday)  PM 13:30 - 15:00

新竹生物醫學園區 生醫產業及育成中心

生醫園區研發大樓  D101 商務中心

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演講大綱

ADC 分子結構複雜，對環境條件敏感，因此建立高通量、自動化的分析流程是開發成功的關鍵。Aunty 可同時分析 96 個樣品的熱穩定性，是進行 formulation screening 的利器，可快速找出最穩定的 Clone、buffer、pH 與添加劑組合。Stunner 緊接著提供濃度、粒徑與 DAR（Drug-to-Antibody Ratio）等關鍵資訊，協助全面評估樣品的品質與一致性。最後透過 Unagi 執行高通量 buffer exchange，有效簡化前處理流程。Aunty、Stunner 與 Unagi 串接為一條整合式 ADC 分析流程，大幅提升效率與數據可靠性，讓開發決策更快速、更有信心。

Abstract

ADCs are structurally complex and highly sensitive to formulation conditions, making a high-throughput, automated workflow essential. Aunty performs thermal stability analysis on 96 samples simultaneously, making it ideal for formulation screening—rapidly identifying the most stable clone, buffer, pH, and excipient combinations. Stunner follows with key measurements including concentration, particle size, and Drug-to-Antibody Ratio (DAR), providing comprehensive insights into sample quality and consistency. Unagi completes the workflow with automated high-throughput buffer exchange, simplifying preparation across test conditions. Together, Aunty, Stunner, and Unagi deliver a powerful, integrated platform for efficient and reliable ADC characterization—enabling faster, smarter development decisions.

Speaker

Martha Perez Ph.D.

Senior Director  Unchained Labs

Casting

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