HUMIMIC Chips — 為您的研究配置專屬器官晶片

The HUMIMIC Chips series, developed by TissUse GmbH (Berlin, Germany), represents a comprehensive lineup of microfluidic multi-organ-chip (MOC) systems designed to recapitulate human organ physiology for preclinical research. The series encompasses four main product lines—HUMIMIC Chip2, Chip3, Chip4, and the in-development ChipXX/ChipXY—each offering increasing levels of organ system complexity to meet diverse research requirements in drug development, toxicology, cosmetic safety testing, and personalized medicine.

All HUMIMIC Chips share a common structural architecture: a polycarbonate adapter plate, a PDMS (polydimethylsiloxane) microfluidic layer, and a glass microscopic slide conforming to ISO 8037/1 standards. Cell culture compartments are fabricated from PEEK and polycarbonate, with MVQ 70A silicone sealings. The on-chip pump mechanism employs three 500 µm-thick pump membranes per circuit, driven by alternating positive air pressure and vacuum to generate physiologically relevant pulsatile flow. This design enables near-lifelike nutrient and oxygen delivery without the need for external peristaltic pumps, while also applying controlled physiological shear stress to cultured tissues.

HUMIMIC Chip2 supports the simultaneous co-culture of two distinct organ models within a shared microfluidic circuit. Available in both 24-well format (∅ 14 mm compartments, microfluidic volume 6.5 µl, surface 145 mm²) and 96-well format (∅ 6.5 mm compartments), a single Chip2 contains two independent microfluidic circuits enabling parallel experiments. The system is compatible with biological barrier models such as intestinal epithelium, lung, and skin, as well as three-dimensional spheroidal and matrix-embedded cultures for parenchymal organ models like the liver. Chip2 is designed for non-invasive in-process monitoring via fluorescence microscopy and other optical methods.

HUMIMIC Chip3 and Chip3plus extend this capability to three organ models, featuring compartments of varying sizes for enhanced combinatorial flexibility. Chip3 carries a microfluidic volume of 10 µl and a surface area of 235 mm², with channel dimensions of 100 µm height by 500 µm width. The enlarged compartment options in Chip3 and Chip3plus make these systems particularly suitable for gut-liver-kidney axis studies and complex multi-tissue interaction research.

HUMIMIC Chip4 enables integration of up to 4+1 organ models—for example, combining intestine, liver, and neuronal tissue in the main circuit, with kidney occupying a dedicated secondary circuit to independently model excretion and reabsorption. Its distinctive PBPK (Physiologically Based Pharmacokinetic)-compliant dual-circuit design supports quantitative in vitro to in vivo extrapolation (IVIVE) and the generation of comprehensive ADME (absorption, distribution, metabolism, excretion) profiles, making Chip4 the tool of choice for systemic pharmacokinetic and pharmacodynamic modeling.

HUMIMIC ChipXX and ChipXY (currently in development) represent the pinnacle of the HUMIMIC Chips roadmap. These chips aim to reproduce systemic models of the female (XX) and male (XY) human body respectively, enabling a true Patient-on-a-Chip approach. Once completed, these systems are designed to generate data previously accessible only through Phase I and Phase II clinical trials, and to substantially reduce the scale of animal testing in drug development pipelines.

All HUMIMIC Chips support three cell culture strategies: cultivation within standard cell culture inserts (Transwell® and Millicell® compatible) on porous membranes for barrier models; direct cultivation in the microfluidic flow alongside 3D scaffolds or hydrogels; and seeding of endothelial cells directly within microchannels. Substance application can be performed either apically (on top of barrier tissues) or systemically (directly into the circulating medium to simulate intravenous delivery). The chips are compatible with cell lines, primary cells, iPS-derived models, biopsies, tissue sections, and commercially available organ models, and integrate seamlessly with HUMIMIC iPSC products.

HUMIMIC Chips are operated in conjunction with HUMIMIC control units—the HUMIMIC Starter for standard laboratory use or the HUMIMIC AutoLab for automated, higher-throughput workflows. Chips are shipped pre-filled with PBS and must be stored at 2°C to 8°C; guaranteed shelf life is 7 days post-delivery, extendable by replacing PBS with PBS containing antibiotics. All HUMIMIC Chips are single-use products and should be sterilized prior to disposal.

J&H Technology（博克科技）is the authorized distributor of TissUse HUMIMIC products in Taiwan, providing consultation, procurement, and technical support for the full HUMIMIC Chips series. For product inquiries, pricing, or technical assistance, please contact our team directly.