實驗動物超音波顯影劑專家

Viscover PolySon™ series represents the gold standard in preclinical ultrasound contrast agents, featuring unique hard-shell polymeric microbubbles specifically engineered for advanced animal imaging research. Our comprehensive portfolio includes three specialized formulations: PolySon™ L for low acoustic pressure perfusion imaging, PolySon™ H for high acoustic pressure surface measurements, and PolySon™ T for optimized tumor visualization.

These innovative hard-shell microbubbles offer unprecedented single particle sensitivity and exceptional echogenicity across all commonly used ultrasound frequencies, including high-frequency microscopy applications above 30 MHz. The stable inert polymeric shell structure enables tunable acoustic properties, making PolySon agents compatible with various ultrasound techniques including harmonic imaging, subharmonic imaging, B-mode imaging, and advanced stimulated acoustic emission (SAE) methods.

PolySon™ L (Order No. 130-095-150/151) is specifically formulated for organ perfusion measurements and cardiac imaging. With a particle size of 1-3 µm, it delivers optimal contrast at microscopic resolutions and excels in myocardial perfusion studies using low mechanical index SAE techniques. The agent circulates in the blood pool for up to 10 minutes post-injection and is taken up by the reticuloendothelial system (RES) in liver and spleen.

PolySon™ H (Order No. 130-095-152/153) features highly robust microbubbles optimized for high acoustic pressure imaging of liver parenchyma. This formulation is perfectly suited for high mechanical index SAE imaging, generating distinctive pseudo-Doppler effects from bubble rupture that enable sensitive particle acoustic quantification (SPAQ). It maintains stability under high-energy ultrasound beams, making it ideal for body surface measurements and deep tissue assessment.

PolySon™ T (Order No. 130-095-148/149) represents a breakthrough in tumor imaging, combining exceptionally high contrast enhancement with an extended blood half-life. This specialized formulation significantly improves visualization of vascularized tumors in animal models, including hepatocellular carcinoma (HCC), subcutaneous xenografts, and orthotopic tumor models. The prolonged circulation time provides an extended imaging window for comprehensive tumor perfusion assessment and treatment monitoring.

All PolySon products are compatible with major preclinical ultrasound platforms including Vevo (VisualSonics), Prospect (S-Sharp), and Sonix (Ultrasonix) systems. They support multiple imaging modalities and enable quantitative perfusion analysis through advanced techniques like SPAQ, making them indispensable tools for cardiovascular research, oncology studies, and organ perfusion investigations in small animal models such as mice, rats, and hamsters.

Viscover also offers customized imaging agent development services for specialized research applications, including surface functionalization for molecular imaging, drug-loaded therapeutic microbubbles, and multimodal contrast agents. Our scientific team provides comprehensive technical support, application guidance, and training to ensure successful implementation in your research program. Contact JNH Technologies for detailed product information, ordering, and technical consultation.