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釋放高通量實驗的無限潛能
承襲 Freeslate 頂尖自動化技術，Big Kahuna 與 Junior 模組化平台每週執行數百次平行實驗，涵蓋 Biologics 配方篩選、製程化學與小分子開發，加速您的每一步研發進程
技術背景：源自 Freeslate 的頂尖自動化技術
Unchained Labs 的實驗室自動化產品線源自對 Freeslate 的策略性併購。Freeslate 是高通量實驗（High-Throughput Experimentation, HTE）領域的先驅，擁有超過二十年的技術積累，其自動化平台廣泛應用於全球頂尖製藥與化學企業。
透過此次整合，Unchained Labs 將 Freeslate 久經驗證的自動化技術與自身在生物分析領域的專業知識相結合，打造出功能更強大、應用更廣泛的新一代實驗室自動化解決方案。Big Kahuna 與 Junior 兩大平台正是這項技術傳承的具體體現，為研發團隊提供從桌上型到端到端完整工作流程的彈性選擇。
核心優勢
模組化設計
高度可配置的工作平台，依據實驗需求自由組合功能模組
高通量能力
每週可執行數百次平行實驗，大幅縮短研發週期
跨領域應用
涵蓋 Biologics、Process Chemistry 與 Small Molecule 三大應用領域
數據整合
LEA 軟體平台實現實驗設計、執行與分析的無縫串聯
Big Kahuna：端到端完整自動化工作站
Big Kahuna 是 Unchained Labs 最具彈性的大型自動化工作站，專為需要端到端完整工作流程的研發團隊設計。從樣品製備、反應執行到分析檢測，Big Kahuna 能將整個實驗流程自動化，讓研究人員專注於科學決策而非繁瑣操作。
主要功能模組
Buffer Exchange Module 自動化緩衝液置換，支援最多 96 個樣品同步處理
Multi-channel pH Probe 4 通道 pH 探針，30 分鐘內完成 96-well plate 量測
Viscosity Station 自動化黏度量測，適用於 Newtonian 與 non-Newtonian 流體
Visual Inspection Station 整合色度、濁度與可見微粒計數的三合一檢測
Heating/Cooling/Stirring Station 精準溫度控制與攪拌，支援加速穩定性試驗
Solid Dispensing Tools 自適應學習演算法，精準分配粉末與固體試劑
Optimization Sampling Reactor (OSR) 即時取樣反應器，可從 8 個壓力/溫度控制反應槽中取樣
Screening Pressure Reactor (SPR) 支援高達 400°C 與 200 bar 的極端條件反應篩選
Junior：靈活配置的桌上型自動化平台
Junior 是專為桌上型應用設計的模組化自動化平台，體積精巧但功能強大。無論是配方篩選、反應優化或樣品製備，Junior 都能將繁瑣的手動操作轉化為標準化的自動流程，讓研究人員設定好參數後即可離開，大幅提升實驗效率與再現性。
主要功能模組
4-Tip pH Probe 高解析度 4 探針 pH 量測，含自動校正與清洗功能
Viscosity Station 僅需 100 µL 樣品，6 分鐘內完成黏度量測
Visual Inspection Station 非破壞性檢測，影像自動存檔供後續比對分析
Heated 4-Tip Liquid Dispenser 加熱型液體分配器，適用於高黏度或易結晶樣品
Vortexing Station 自動化渦旋混合，支援 freeze/thaw 應力測試
Crystallization Assembly 8 x 12 陣列結晶組件，支援 XRD 與 Raman 光譜分析
Big Kahuna vs Junior 快速比較
| 特性 | Big Kahuna | Junior |
|---|---|---|
| 定位 | 端到端完整工作流程 | 桌上型靈活配置 |
| 工作平台規模 | 大型多模組整合 | 精巧模組化設計 |
| 平行實驗能力 | 數百次/週 | 數百次/週 |
| 壓力反應支援 | SPR 支援 400°C / 200 bar | 可整合 SPR |
| 即時取樣 | OSR 8 槽同步取樣 | OSR 8 槽同步取樣 |
| 適用對象 | 需完整自動化流程的核心實驗室 | 空間有限或特定應用的研究團隊 |
應用領域
Big Kahuna 與 Junior 平台涵蓋三大核心應用領域，從生物製藥到小分子藥物開發，提供完整的高通量實驗解決方案。
Biologics Formulation
生物製藥配方開發
自動化整個生物製藥配方開發流程，從 buffer prep、buffer exchange、pH 檢測到樣品製備與分析。整合樣品培養與自動化 freeze/thaw 系統，加速穩定性研究。在有限材料下完成更多 developability 評估與 formulation screening。
- Characterize formulations with limited material
- Developability and preformulation screens
- Robustness and stress studies
- Measure pH, viscosity, turbidity and visible particles
Process Chemistry
製程化學優化
針對 reaction screening 與 catalysis optimization 提供完整自動化方案。透過 array-based、micro-scale 的處理方式，同時篩選離散變數（catalyst precursors、ligands）與連續變數（temperature、pressure、time），快速找到最佳反應條件。
- Process optimization
- Screen continuous and discrete variables
- Optimize catalyst loading
- Real-time reaction kinetics with OSR
Small Molecule Preformulation
小分子藥物前配方開發
提供自動化、高通量的端到端解決方案，全面分析藥物候選物的物理化學特性。在更早的開發階段篩選更多結構與條件，快速找到最佳 druggable form，加速從發現到臨床的進程。
- Solubility screening
- Crystallization and polymorph screening
- Powder dispensing
- Reaction screening and optimization
LEA 軟體：打破數據瓶頸的智慧核心
LEA（Library Studio、Automation Studio、PolyView 的整合平台）是驅動 Big Kahuna 與 Junior 的核心軟體系統。它不僅控制自動化硬體，更將實驗設計、執行與數據分析串聯成完整的工作流程，讓研究人員能夠輕鬆管理高通量實驗產生的大量數據。
Library Studio
以陣列形式設計複雜的高通量實驗，直覺化介面讓多變數實驗規劃變得簡單
Automation Studio
執行設計好的實驗並整合分析儀器，實現真正的無人值守自動化運行
PolyView
檢視與報告所有實驗設計、執行與分析數據，支援決策導向的數據視覺化
LEA 核心價值
- 將實驗條件、步驟與分析數據自動關聯，產出的報告不只有數字，更有完整的決策依據
- 支援與 Unchained Labs 及第三方分析儀器的整合，建構統一的數據生態系
- 直覺化的前端設計介面，搭配強大的後端數據整合能力，徹底消除工作流程瓶頸
常見問題
Unchained Labs Laboratory Automation: Big Kahuna and Junior High-Throughput Platforms
Unchained Labs offers industry-leading laboratory automation solutions through its Big Kahuna and Junior platforms, built upon the proven high-throughput experimentation (HTE) technology acquired from Freeslate. These modular automation systems empower research teams to execute hundreds of parallel experiments per week, dramatically accelerating drug discovery and development timelines across biologics, process chemistry, and small molecule applications.
Big Kahuna represents the ultimate configurable end-to-end workflow solution for laboratories requiring comprehensive automation coverage. This large-scale platform integrates multiple functional modules including buffer exchange systems capable of processing up to 96 samples simultaneously, multi-channel pH probes that complete 96-well plate measurements in under 30 minutes, automated viscosity stations for both Newtonian and non-Newtonian fluids, and visual inspection stations combining color, turbidity, and visible particle counting in a single non-destructive assay. For process chemistry applications, Big Kahuna supports the Optimization Sampling Reactor (OSR) for real-time reaction kinetics from up to 8 pressure and temperature-controlled vessels, and the Screening Pressure Reactor (SPR) enabling reactions at extreme conditions up to 400°C and 200 bar (3000 psi).
Junior delivers the same high-throughput capabilities in a compact benchtop format, ideal for research teams with space constraints or specific application focus. The platform features configurable deck layouts with modules for pH measurement, viscosity analysis, visual inspection, heated liquid dispensing, and crystallization screening. Junior's 8x12 array crystallization assembly with universal substrate plates enables direct sample analysis by birefringence, XRD, and Raman spectroscopy without crystal manipulation.
Both platforms are powered by LEA software, an integrated suite comprising Library Studio for array-based experimental design, Automation Studio for execution and instrument integration, and PolyView for comprehensive data review and reporting. LEA automatically links experimental conditions, process steps, and analytical data, ensuring final reports contain complete decision-support information rather than just numerical results. The software supports integration with both Unchained Labs analytical instruments and third-party equipment including UV/Vis, DLS, HPLC, and CE systems.
In biologics formulation development, these platforms automate the entire workflow from buffer preparation and exchange through pH monitoring, sample preparation, and analytics. Integrated sample incubation and automated freeze/thaw systems enable accelerated stability studies, while the ability to characterize formulations with limited material allows more comprehensive developability and preformulation screening. For process chemistry, the platforms screen discrete variables such as catalyst precursors and ligands alongside continuous variables including temperature, pressure, and reaction time, enabling identification of optimal conditions for yield, selectivity, and synthetic route optimization. Small molecule preformulation applications benefit from automated solubility screening, crystallization and polymorph screening, precise powder dispensing with adaptive learning algorithms, and temperature-controlled pipetting and filtration to maintain API solubility throughout processing.
The modular architecture of both Big Kahuna and Junior allows complete customization to match specific workflow requirements. Research teams can select from battle-tested module combinations or work with Unchained Labs experts to configure novel automation solutions for previously unautomated processes. This flexibility, combined with robust data integration through LEA software, positions Unchained Labs automation platforms as essential tools for modern pharmaceutical and chemical research laboratories seeking to maximize experimental throughput while maintaining data quality and reproducibility.
