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TissUse HUMIMIC控制單元－器官晶片的動力心臟

TussUse HUMIMIC 多器官晶片控制器

TissUse提供多種HUMIMIC控制單元 - 它們是我們HUMIMIC技術的基礎。不論是基本單元還是自動化實驗室，能夠滿足各種需求和要求。

HUMIMIC Starter – 擁有24個幫浦、可同時控制8個生物晶片的小英雄

HUMIMIC Starter - 您多器官晶片的起始點

The HUMIMIC Starter delivers 24 pre-calibrated pneumatic connectors for optimal operation of the on-chip pumps., HUMIMIC Starter
HUMIMIC Starter 是TissUse器官晶片最小的微生理環境動力來源，大小僅251.2 mm x 206 mm x 150.2 mm，卻集成24個預先校準的氣閥、7”彩色觸控面板，可顯示與調整幫浦作動的壓力與頻率，範圍從每分鐘3次到120次．還配備了一個USB端口，用於輕鬆管理壓力曲線和數據傳輸。HUMIMIC Starter兼容HUMIMIC Chip2 96孔、Chip2 24孔、Chip3、Chip3plus和Chip4。

其特點如下：

能夠操作高達8個HUMIMIC Chip3/Chip3plus、4個HUMIMIC Chip2/Chip4，或者它們的組合
24個預校準的壓力連接器，以實現晶片中的最佳體積流動
通過用戶界面可以持續調整壓力和真空
7英寸觸摸屏顯示螢幕
具有3個額外設備連接的設計，如HUMIMIC HeatingSupport和HUMIMIC ActSense
詳細資訊可參考HUMIMIC Starter Quick Guide

HUMIMIC AutoLab – 擁有24個生物晶片容量的全能大傢伙

全自動高通量化器官晶片篩選系統, TissUse AutoLab

HUMIMIC AutoLab是一個小型研究實驗室，可以同時自動操作高達24個多器官晶片。它可以執行HUMIMIC Starter所能執行的一切，而且以自動化和更方便的方式執行更多操作。該系統以最大效率運作，能夠在操作和從我們的HUMIMIC晶片收集數據時創造受控條件。晶片被放置在一個帶有自動加熱的無菌內部區域，系統在實驗期間向晶片供應營養溶液。物質將根據指定的劑量方案自動應用。成像數據可以由集成的明場和螢光顯微鏡記錄。多器官晶片的自動分析確保高度的自主性，並確保測量的一致性。HUMIMIC AutoLab兼容HUMIMIC Chip 2、3和4。

特點

• 可以將高達24個多器官晶片分開培養，溫度範圍在36°C至40°C之間

• BSC II級生物安全柜中提供無菌環境

• 樣品、物質和培養基會自動存儲在4°C

• 具有兩個操作門和耗材供應的高精度三軸定位系統

TissUse automation brochure

HUMIMIC HeatSupport – 可同時提供4個器官晶片溫暖的支援

器官晶片加溫板, TissUse HeatSupport

培養細胞的溫度控制是許多實驗的前提，以確保可重復和標準化的條件。HUMIMIC HeatSupport使得能夠在培養箱外操作晶片成為可能 - 這是一個巨大的優勢，因為培養箱的氛圍對於眾多應用並不是最理想的。將HUMIMIC HeatSupport與HUMIMIC Starter結合使用可以實現對高達4個晶片的獨立溫度控制，從室溫升至42°C - 理想的用於模擬同一實驗中的不同溫度。由於晶片可以與顯微鏡結合使用，使用HUMIMIC HeatSupports，成像應用也容易實現。

HUMIMIC ActSense – 解析生物晶片電性與電刺激的解決方案

HUMIMIC ActSense將刺激和感測功能結合在單一的多功能系統中。因此，它使您能夠感知和控制您的器官培養的電性特性。

HUMIMIC ActSense和HUMIMIC Chip2 24孔的示範設置。下圖：電極設計、功能和配置。, HUMIMIC ActSense

（上圖：HUMIMIC ActSense和HUMIMIC Chip2 24孔的示範設置。下圖：電極設計、功能和配置。, HUMIMIC ActSense）

儘管簡單的TEER測量已成功用於評估內皮或上皮模型的連接動態和屏障完整性，但HUMIMIC ActSense還執行電阻抗光譜技術，以探測培養組織的電子足跡，例如，評估不同細胞類型在不同成熟階段的生長、擴散和分化。

通過8組（16個單端）感測站的同時記錄細胞的電活動，這允許感測，例如，心臟動作電位，以更好地理解和評估心臟組織的行為和健康。多種刺激方案可以用來最初促進成熟，最終對成熟心肌細胞的跳動進行節奏控制。

功能特性：

Impedance spectroscopy – TEER

1x channel / 8x channel through multiplexing.
Single-frequency (TEER): 96-/24-well.
Multi-Frequency measurements (impedance spectroscopy).
Frequency Range: 10 Hz-100 kHz.
Frequency Resolution: 0.1 Hz.
ECG – EMG – EEG

Brain (EEG), muscle (EMG), and heart (ECG) activity recording.

8x differential channel (16x single ended sensing sites).
24-Bit channel resolution: down to micro Volts.
Gain: 1x, 2x, 4x, 6x, 8x, 12x, 24x.
Data rates: up to 16 ksps.

Stimulation

1x channel / 8x channel through multiplexing.
Multiple voltage stimulation profiles (square, sine, train of impulses).
Stimulation frequency: 0 Hz - 10 MHz.
Cyclic stimulation possible.
Gain: 1.5x, 2x, 2.5x, 5x.
Attenuation: 1x, 10x, 100x, 1000x.

Poster 下載

The HUMIMIC ActSense: a multifunctional device to incorporate electrical functionalities into microphysiological culture systems

Description

HUMIMIC Starter – Our specialist for individual missions

Compact yet powerful, the HUMIMIC Starter is your ticket to the world of superheroes. Whether as a stand-alone unit or in a combination of multiple devices, it can do everything from basic research to complex studies.

HUMIMIC Starter

HUMIMIC AutoLab – Our answer to the big questions

Concentrated research power to meet the biggest challenges and enable large-scale experiments. The HUMIMIC AutoLab can independently run up to 24 chips simultaneously. It can do everything the HUMIMIC Starter can do, and a lot more in an automated and more convenient way.

HUMIMIC AutoLab

HUMIMIC HeatSupport

The cultivation of cells at regulated temperature is a prerequisite for many experiments in order to ensure reproducible and standardized conditions. The HUMIMIC HeatSupport makes it possible to operate chips outside an incubator - a big advantage, since the incubator atmosphere is not optimal for numerous applications. Operation of the HUMIMIC HeatSupport in combination with the HUMIMIC Starter allows an independent temperature control of up to 4 chips from room temperature up to 42 °C - ideal to simulate different temperatures in one experiment. Since the chips can be operated in combination with a microscope using HUMIMIC HeatSupports, imaging applications are also easy to implement.

HUMIMIC ActSense – An electrifying combination of action and sensation

A Multi-Organ-Chip needs a true multi-tasker when it comes to electric applications and readouts. Our HUMIMIC ActSense combines TEER measurements, impedance spectroscopy, high resolution sensing and stimulation of electrically active tissue, using one single device.

HUMIMIC ActSense