Cue細胞收集暨凍存分裝充填系統

Cue是一款自動化的小體積細胞處理系統。無論您是要進行細胞凍存的前配製、分裝到多個最終產品袋中，還是欲執行小體積的細胞收集、清洗、濃縮、培養液置換、電穿孔前製備、凍存液添加等程序，Cue都支援這些細胞和基因治療製劑製造的工作流程。

Cue 具備跟LOVO 一樣的 Membrane Filtration Technology

利用Size Filtration的原理，讓細胞在全懸浮 (Continuous Diafiltration)、密閉且無菌的狀態下，自動化的進行細胞樣本的清洗、血小板去除、Sample Washing、Volume reduction、Medium exchange、Cryopreservation Preparation 、Product formulation、及final product filling等製程工作。

具備低溫控制的細胞凍存前處理功能

Cue具備3-22°C 溫度控制、及Shaking Mixing Module，細胞經過收集清洗及濃縮後，可以在低溫的環境下，進行凍存液添加及體積濃度調整，以確保細胞活性，並確保細胞調整至合適的濃度及凍存液比例中。

無菌、精準、多袋小體積的自動充填功能

具備Dual Syringe Module，搭配IR detector Array技術，Cue可以進行精準、小體積的細胞製程處理，收集完的細胞、或經凍存液添加的細胞製劑，可以進行最小達2ml、多袋數的無菌自動充填。Cue更具備Air removal 功能，可移除最終產品袋充填後的多餘空氣，讓細胞製劑的凍存保存更加安全，確保了凍存細胞的品質。

英文說明

Cue^® Small Volume Cell Processing System

Proven membrane filtration technology, reimagined.

By utilizing the same separation technology as the LOVO Cell Processing System, Cue is an automated small volume cell processing system that addresses critical unmet needs. Whether you are looking to cell concentration, washing, formulate and aliquot into multiple final product bags, or perform a small volume electroporation preparation procedure, Cue supports these various cell and gene therapy manufacturing workflows.

Unmatched precision and control at small volumes

Cue’s novel syringe pumps and valving cassette give it unmatched precision and control at small volumes.
By combining our functionally-closed syringe pumps, valving cassette, and our spinning membrane separation technology, Cue enables high accuracy concentration, formulation, and aliquoting.

Additional Features:
Cue supports the following applications:
• Cryopreservation Preparation (e.g., final fill and finish)
• Small Volume Culture Media Exchange
• Electroporation Preparation

Major features and benefits of the Cue Cell processing:
• Capable of producing final product volumes as small as 2 mL
• User defined type and number of final product containers (e.g., aliquots)
• On-instrument wash and concentration steps
• Temperature controlled (3-22°C) with automated mixing
• 4 μm Spinning Membrane Filter