HUMIMIC 控制單元
驅動器官晶片的動力心臟

The HUMIMIC Devices series by TissUse represents the cornerstone of the HUMIMIC organ-on-chip technology platform. Designed as precision control units for Multi-Organ-Chips, HUMIMIC instruments provide the physiologically relevant dynamic environment required for multi-organ co-culture, drug testing, toxicology studies, and ADME analysis in vitro.

At the heart of the system is the on-chip pump technology: each HUMIMIC Chip circuit integrates three pneumatic pump membranes (500 µm thick), driven by alternating positive pressure and vacuum supplied by the control unit. This generates a pulsatile, peristaltic-like flow that mimics the rhythmic circulation of the cardiovascular system. Users can precisely control pumping pressure (mbar) and frequency (Hz). The system simultaneously monitors and logs real-time pressure readings across all channels, triggering high/low pressure alerts when values fall outside the defined thresholds to ensure stable and reproducible experimental conditions.

The HUMIMIC Starter is a compact yet powerful entry-level control unit featuring 24 pre-calibrated pneumatic connectors, a 7-inch touch display, and three expansion ports for accessories such as HUMIMIC HeatSupport and HUMIMIC ActSense. It is compatible with HUMIMIC Chip2, Chip3, Chip3plus, and Chip4, and can operate up to 8x Chip3/Chip3plus or 4x Chip2/Chip4 simultaneously — or any combination thereof. Multiple Starter units can be combined to scale up experimental capacity.

The HUMIMIC AutoLab elevates organ-on-chip research to a new level of automation. This fully automated micro-laboratory can independently run up to 24 Multi-Organ-Chips in parallel within a Class BSC II biosafety cabinet. It features automatic nutrient media supply, substance dosing according to predefined protocols, 4°C cold storage for samples and reagents, a high-precision 3-axis positioning system, and an integrated bright-field and fluorescence microscope for automated imaging. The AutoLab is compatible with HUMIMIC Chip2, Chip3, and Chip4.

The HUMIMIC HeatSupport module enables temperature-controlled chip operation outside of an incubator, supporting independent thermal regulation of up to 4 chips across a range from room temperature to 42°C. Its removable bottom panel facilitates microscopy imaging applications, making it ideal for live-cell imaging workflows in combination with the HUMIMIC Starter.

The HUMIMIC ActSense is a multifunctional electrophysiology device that combines stimulation and sensing in a single instrument. It supports TEER measurements and multi-frequency impedance spectroscopy (10 Hz – 100 kHz) for barrier integrity assessment, ECG/EMG/EEG recording with 24-bit resolution via 8 differential and 8 single-ended channels, and electrical stimulation with configurable waveforms (square, sine, pulse train) up to 10 MHz. The ActSense connects to HUMIMIC Chips equipped with PEDOT:PSS transparent polymer electrodes, enabling simultaneous electrophysiology and optical microscopy without interference.

Together, HUMIMIC Devices form a modular, scalable organ-on-chip instrumentation platform suited for applications including multi-organ crosstalk modeling, organ-on-chip drug development, preclinical drug screening, in vitro toxicology, ADME/IVIVE studies, and 3R animal replacement research. The system supports human-relevant preclinical models that better predict clinical outcomes compared to traditional animal testing methods.